Scientific interest:

  1. Protein kinase CK2 and its participation in cell cycle processes.
  2. Modulators of enzymatic activities (natural and synthetic inhibitors).
  3. Research on the mechanism of action in case of inhibitors (interaction inhibitor/enzyme, enzyme/substrate, inhibitor/substrate).
  4. Estimation of antiproliferating activity in cell culture and cytotoxicity tests.
  5. Antibacterial and antifungal activity of natural and synthetic compounds.
  6. Genetics and molecular cytogenetics, chromosome and karyotype structure, repetitive DNA sequences, meiosis; translocation.
  7. Chromosome rearrangements in vivo and in vitro; structure of interphase nuclei.
  8. Research on probiotics - its features and antimicrobiological activities.
  9. Molecular diagnostics of microorganisms isolated from natural environments.

Employes:

Ryszard Szyszka, Prof., Ph. D., D. Sc.

Fields of interest: molecular biology, enzymology, proteomics, protein kinases structure and regulation.

Current research:

    1. Janeczko M., Orzeszko A., Kazimierczuk Z., Szyszka R., Baier A. CK2α and CK2α′ subunits differ in their sensitivity to 4,5,6,7-tetrabromo- and 4,5,6,7-tetraiodo-1H-benzimidazole derivatives. Eur. J. Med. Chem. 2012, 47: 345-350. DOI: 10.1016/j.ejmech.2011.11.002.
    2. Baier A., Galicka A., Nazaruk J., Szyszka R. Selected flavonoid compounds as promising inhibitors of protein kinase CK2α and CK2α', the catalytic subunits of CK2. Phytochem. 2017, 136: 39-45. DOI: 10.1016/j.phytochem.2016.12.018.
    3. Baier A., Nazaruk J., Galicka A., Szyszka R. (2018) Inhibitory influence of natural flavonoids on human protein kinase CK2 isoforms - effect of the regulatory subunit. Mol. Cell. Biochem. 2018, 444: 35-42. DOI: 10.1007/s11010-017-3228-1.

International cooperation:
Department of Chemistry, University of Massachusetts Boston

e-mail: szyszkar [at] kul.pl

 

Hieronim Golczyk, Ph. D., D. Sc.

Fields of interest: molecular cytogenetics; genetics; chromosomes; karyotype evolution; chromatin.

Current research:

    1. Sobanski J., Giavalisco P., Fischer A., Kreiner J.M., Walther D, Schöttler M.A., Pellizzer T., Golczyk H., Obata T., Bock R., Sears B.B., Greiner S. 2019. Chloroplast competition is controlled by lipid biosynthesis in evening primroses. Proc. Natl. Acad. Sci. USA 116: 5665-5674. DOI: 10.1073/pnas.1811661116.
    2. Golczyk H., Massouh A., Greiner S. 2014. Translocations of chromosome end-segments and facultative heteroch`romatin promote meiotic ring formation in evening primroses. Plant Cell 26: 1280-1293. DOI: 10.1105/tpc.114.122655.
    3. Fuentes I., Stegemann S., Golczyk H., Karcher D., Bock R. 2014. Horizontal genome transfer as an asexual path to the formation of new species. Nature 511: 232-235. DOI: 10.1038/nature13291.

International cooperation:

Max Planck Institute of Molecular Plant Physiology. Potsdam-Golm, Germany.

E-mail: golczyk [at] kul.pl

 

Konrad Kubiński, Ph. D., D. Sc.

Fields of interest:  protein kinases, antifungal agents, natural compounds, inhibitors of steroid sulfatase

Current research:

    1. Daśko M., Demkowicz S., Biernacki K., Harrous A., Rachon J., Kozak W., Martyna A., Masłyk M., Kubiński K., Boguszewska‐Czubara A. Novel steroid sulfatase inhibitors based on N‐thiophosphorylated 3‐(4‐aminophenyl)‐coumarin‐7‐O‐ sulfamates. Drug Dev. Res. 2019, 80(6). DOI: 10.1002/ddr.21569.
    2. Masłyk M., Janeczko M., Martyna A., Czernik S., Tokarska-Rodak M., Chwedczuk M., Foll-Josselin B., Ruchaud S., Bach S., Demchuk O.M., Kubiński K. The Anti-Candida albicans Agent 4-AN Inhibits Multiple Protein Kinases. Molecules 2019, 24(1): 153. DOI:10.3390/molecules24010153.
    3. Masłyk M., Janeczko M., Martyna A., Kubiński K. CX-4945: the protein kinase CK2 inhibitor and anti-cancer drug shows anti-fungal activity. Mol. Cell. Biochem. 2017, 435(1). DOI:10.1007/s11010-017-3068-z.

International cooperation:

Stéphane Bach, Sorbonne Université, USR3151 CNRS/UPMC, Plateforme de criblage KISSf (Kinase Inhibitor Specialized Screening Facility).

E-mail: konrad.kubinski [at] kul.pl

 

Maciej Masłyk, Ph.D., D.Sc.

Fields of interest: molecular biology, bioactive compounds, biotechnology, antimicrobial agents
Current research:

    1. Ravichandiran P., Boguszewska-Czubara A., Masłyk M., Antony B., Sivakumar S., Johnson P.M., Shim K.S., Kim H.-G., Yoo D.J. Naphthoquinone-Based Colorimetric and Fluorometric Dual-Channel Chemosensor for the Detection of Fe2+ Ion and Its Application in Bio-Imaging of Live Cells and Zebrafish. ACS Sustainable Chem. Eng. 2019 (20): 17210-17219. DOI: 10.1021/acssuschemeng.9b03822.
    2. Masłyk M., Janeczko M., Martyna A., Czernik S., Tokarska-Rodak M., Chwedczuk M., Foll-Josselin B., Ruchaud S., Bach S., Demchuk O.M., Kubiński K. The Anti-Candida albicansAgent 4-AN Inhibits Multiple Protein Kinases. Molecules. 2019, 24(1). pii: E153. DOI: 10.3390/molecules24010153.
    3. Olech M., Nowacka-Jechalke N., Masłyk M., Martyna A., Pietrzak W., Załuski D., Nowak R., Kubiński K. Polysaccharide-Rich Fractions from Rosa rugosa Thunb. - Composition and Chemopreventive Potential. Molecules 2019; 24(7)., pii: E1354.  DOI:10.3390/molecules24071354.

International cooperation:
1. Department of Life Sciences, College of Natural Sciences, Chonbuk National University, South Korea.

    1. Sorbonne Université, Plateforme de criblage KISSf (Kinase Inhibitor Specialized Screening Facility), Station Biologique, Place Georges Teissier, France.
    2. Instituto Universitario de Bio-Orgánica Antonio González (CIBICAN), Departamento de Química Orgánica,Universidad de La Laguna, Tenerife, Spain.

E-mail: maciekm [at] kul.pl

Monika Janeczko, Ph. D.

Fields of interest: antimicrobial compounds, Candida albicans, mechanisms of pathogenicity of microorganisms

Current research:

    1. Janeczko M., Kochanowicz E. Silymarin, a Popular Dietary Supplement Shows Anti-CandidaActivity. Antibiotics (Basel). 2019, 8(4). pii: E206. DOI: 10.3390/antibiotics8040206.
    2. Ravichandiran P., Masłyk M., Sheet S., Janeczko M., Premnath D., Kim A.R., Park B.H., Han M.K., Yoo D.J. Synthesis and Antimicrobial Evaluation of 1,4-Naphthoquinone Derivatives as Potential Antibacterial Agents. ChemistryOpen.2019 8(5): 589-600. DOI: 10.1002/open.201900077.
    3. Masłyk M., Janeczko M., Martyna A., Czernik S., Tokarska-Rodak M., Chwedczuk M., Foll-Josselin B., Ruchaud S., Bach S., Demchuk O.M., Kubiński K. The Anti-Candida albicansAgent 4-AN Inhibits Multiple Protein Kinases. Molecules. 2019, 24(1). pii: E153. DOI: 10.3390/molecules24010153.

 International cooperation:

    1. Sorbonne Université, Plateforme de criblage KISSf (Kinase Inhibitor Specialized Screening Facility), Station Biologique, Place Georges Teissier, France.
    2. Department of Life Sciences, College of Natural Sciences, Chonbuk National University, South Korea
    3. Instituto Universitario de Bio-Orgánica Antonio González (CIBICAN), Departamento de Química Orgánica,Universidad de La Laguna, Tenerife, Spain

E-mail: mjanec [at] kul.pl

 Monika E. Jach, Ph.D.

Fields of interest: group of lactic acid bacteria, especially Lactobacillus, nutritional yeast like Yarrowia lipolytica, nutritional yeast biomass,  plant-associated endosymbionts e.g. rhizobia
Current research:

    1. Jach M.E., Serefko A. (2020) Role of Natural Agents in Management of Diabetes. In: Promising Drug Molecules of Natural Origin, Editors: Rohit Dutt, Anil K. Sharma, Raj K. Keservani, Vandana Garg, Apply Academic Press.
    2. Jach M.E., Masłyk M., Juda M., Sajnaga E., Malm A. (2018) Vitamin B12-enriched Yarrowia lipolytica biomass obtained from biofuel waste. Waste and Biomass Valorization. DOI: 10.1007/s12649-018-0521-5.
    3. Jach M.E., Serefko A. (2018) Nutritional yeast biomass: characterization and application. In: Diet, Microbiome and Health (Eds: Grumezescu A.,Holban A.M.) Vol.11, pp.237-270. Academic Press. DOI: 10.1016/B978-0-12-811440-7.00009-0.

International cooperation: -

E-mail: monika.jach [at] kul.pl

 

Elżbieta Kochanowicz, Ph.D.

Fields of interest: molecular biology, antimicrobial agents,

Current research:

  1. Janeczko M., Kochanowicz E. Silymarin, a Popular Dietary Supplement Shows Anti-CandidaActivity. Antibiotics (Basel). 2019, 8(4). pii: E206. DOI: 10.3390/antibiotics8040206.

International cooperation:

E-mail: mazure [at] kul.lublin.pl

Ewa Gizińska, M. Sc.

Fields of interest: molecular biology, microbiology, proteins, enzymes
Current research:

  1. Baier A., Alikowska E., Szyszka R. Asf1 protein as modulator of protein kinase CK2 activity. W: Protein Kinase CK2 Cellular Function in Normal and Disease States. (Edytorzy: K. Ahmed, O-G. Issinger, R. Szyszka) Springer, 2015, 3-16

International cooperation: -
E-mail: ewa.alikowska [at] kul.lublin.pl

 

Staff

 

Professor DSc Ryszard Szyszka

Head of the Department

e-mail: szyszkar [at] kul.pl

phone: 48 81 454 54 50

room number: 4.16

 

DSc Hieronim Golczyk

professor

e-mail: golczyk [at] kul.pl

phone: 48 81 454 54 45

room number: 4.17

 

DSc Konrad Kubiński

adjunct

e-mail: kubin [at] kul.pl

phone: 48 81 454 54 23

room number: 4.04

 

DSc Maciej Masłyk

adjunct

e-mail: maciekm [at] kul.pl

phone: 48 81 454 54 51

room number: 4.02

 

Dr Monika Jach

adjunct

e-mail: monijach [at] kul.pl

phone: 48 81 454 54 34

room number: 3.04

 

Dr Monika Janeczko

adjunct

e-mail: mjanec [at] kul.pl

phone: 48 81 454 54 25

room number: 4.03

 

Dr Elżbieta Kochanowicz

assistant

e-mail: mazure [at] kul.pl

phone: 48 81 454 54 25

room number: 4.03

 

MSc Ewa Gizińska

assistant

e-mail: ewunia86 [at] kul.pl

phone: 48 81 454 54 21

room number: 3.03

 

MSc Ewelina Lech-Pituch

senior technical assistant

e-mail: ewelina.lech-pituch [at] kul.pl,

phone: 48 81 454 54 24

room number: 3.18

 

MSc Aleksandra Martyna

senior technical assistant

e-mail: aleksandra.martyna [at] kul.pl

phone: 48 81 454 54 23,

room number: 4.18